Overexpression of PPT2 Represses the Clear Cell Renal Cell Carcinoma Progression by Reducing Epithelial-to-mesenchymal Transition
Identifieur interne : 000086 ( Main/Exploration ); précédent : 000085; suivant : 000087Overexpression of PPT2 Represses the Clear Cell Renal Cell Carcinoma Progression by Reducing Epithelial-to-mesenchymal Transition
Auteurs : Changfei Yuan [République populaire de Chine] ; Zhiyong Xiong [République populaire de Chine] ; Jian Shi [République populaire de Chine] ; Jingtao Peng [République populaire de Chine] ; Xiangui Meng [République populaire de Chine] ; Cheng Wang [République populaire de Chine] ; Wenjun Hu [République populaire de Chine] ; Zeyuan Ru [République populaire de Chine] ; Kairu Xie [République populaire de Chine] ; Hongmei Yang [République populaire de Chine] ; Ke Chen [République populaire de Chine] ; Xiaoping Zhang [République populaire de Chine]Source :
- Journal of Cancer [ 1837-9664 ] ; 2020.
Abstract
Clear cell renal cell carcinoma (ccRCC) is one of the most common malignant tumors of the urinary system and has a poor response to radiotherapy and chemotherapy. To date, it is urgent to find effective biomarkers for the prevention and treatment of ccRCC. The occurrence and development of ccRCC is closely related to metabolic disturbances. Palmitoyl protein thioesterase 2 (PPT2) is a lysosomal thioesterase which is highly associated with metabolism, and it has never been studied in ccRCC. In this study, we first revealed PPT2 is significantly downregulated in ccRCC, and its expression level is highly correlated with clinicopathological parameters of ccRCC patients. Our ROC curve analyses evaluated the potential of PPT2 as a novel diagnostic marker and prognostic factor. Functional experiment results showed overexpression of PPT2 represses the proliferation, migration and invasion of ccRCC cells
Url:
DOI: 10.7150/jca.36477
PubMed: 31956361
PubMed Central: 6959065
Affiliations:
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Biology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan 430030</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Ru, Zeyuan" sort="Ru, Zeyuan" uniqKey="Ru Z" first="Zeyuan" last="Ru">Zeyuan Ru</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Pathogenic Biology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan 430030, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Pathogenic Biology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan 430030</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Xie, Kairu" sort="Xie, Kairu" uniqKey="Xie K" first="Kairu" last="Xie">Kairu Xie</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Pathogenic Biology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan 430030, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Pathogenic Biology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan 430030</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Yang, Hongmei" sort="Yang, Hongmei" uniqKey="Yang H" first="Hongmei" last="Yang">Hongmei Yang</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Pathogenic Biology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan 430030, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Pathogenic Biology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan 430030</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Chen, Ke" sort="Chen, Ke" uniqKey="Chen K" first="Ke" last="Chen">Ke Chen</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Zhang, Xiaoping" sort="Zhang, Xiaoping" uniqKey="Zhang X" first="Xiaoping" last="Zhang">Xiaoping Zhang</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author></analytic><series><title level="j">Journal of Cancer</title><idno type="eISSN">1837-9664</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Clear cell renal cell carcinoma (ccRCC) is one of the most common malignant tumors of the urinary system and has a poor response to radiotherapy and chemotherapy. To date, it is urgent to find effective biomarkers for the prevention and treatment of ccRCC. The occurrence and development of ccRCC is closely related to metabolic disturbances. Palmitoyl protein thioesterase 2 (PPT2) is a lysosomal thioesterase which is highly associated with metabolism, and it has never been studied in ccRCC. In this study, we first revealed PPT2 is significantly downregulated in ccRCC, and its expression level is highly correlated with clinicopathological parameters of ccRCC patients. Our ROC curve analyses evaluated the potential of PPT2 as a novel diagnostic marker and prognostic factor. Functional experiment results showed overexpression of PPT2 represses the proliferation, migration and invasion of ccRCC cells <italic>in vitro</italic>. Mechanistic investigations demonstrated that overexpression of PPT2 represses the ccRCC progression by reducing epithelial-to-mesenchymal transition (EMT). In conclusion, PPT2 is downregulated in ccRCC. Decreased PPT2 expression may be considered as a novel diagnostic marker and prognostic factor and serve as a therapeutic target for ccRCC.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Rueckert, J" uniqKey="Rueckert J">J Rueckert</name></author><author><name sortKey="Devitt, K" uniqKey="Devitt K">K Devitt</name></author><author><name sortKey="Gardner, Ja" uniqKey="Gardner J">JA Gardner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rini, Bi" uniqKey="Rini B">BI Rini</name></author><author><name sortKey="Campbell, Sc" uniqKey="Campbell S">SC Campbell</name></author><author><name sortKey="Escudier, B" uniqKey="Escudier B">B Escudier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Srigley, Jr" uniqKey="Srigley J">JR Srigley</name></author><author><name sortKey="Delahunt, B" uniqKey="Delahunt B">B Delahunt</name></author><author><name sortKey="Eble, Jn" 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Y">Y Wei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ahmed, N" uniqKey="Ahmed N">N Ahmed</name></author><author><name sortKey="Maines Bandiera, S" uniqKey="Maines Bandiera S">S Maines-Bandiera</name></author><author><name sortKey="Quinn, Ma" uniqKey="Quinn M">MA Quinn</name></author><author><name sortKey="Unger, Wg" uniqKey="Unger W">WG Unger</name></author><author><name sortKey="Dedhar, S" uniqKey="Dedhar S">S Dedhar</name></author><author><name sortKey="Auersperg, N" uniqKey="Auersperg N">N Auersperg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tan, Rj" uniqKey="Tan R">RJ Tan</name></author><author><name sortKey="Zhou, D" uniqKey="Zhou D">D Zhou</name></author><author><name sortKey="Zhou, L" uniqKey="Zhou L">L Zhou</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clevers, H" uniqKey="Clevers H">H Clevers</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Hubei</li></region><settlement><li>Wuhan</li></settlement></list><tree><country name="République populaire de Chine"><region name="Hubei"><name sortKey="Yuan, Changfei" sort="Yuan, Changfei" uniqKey="Yuan C" first="Changfei" last="Yuan">Changfei Yuan</name></region><name sortKey="Chen, Ke" sort="Chen, Ke" uniqKey="Chen K" first="Ke" last="Chen">Ke Chen</name><name sortKey="Hu, Wenjun" sort="Hu, Wenjun" uniqKey="Hu W" first="Wenjun" last="Hu">Wenjun Hu</name><name sortKey="Meng, Xiangui" sort="Meng, Xiangui" uniqKey="Meng X" first="Xiangui" last="Meng">Xiangui Meng</name><name sortKey="Peng, Jingtao" sort="Peng, Jingtao" uniqKey="Peng J" first="Jingtao" last="Peng">Jingtao Peng</name><name sortKey="Ru, Zeyuan" sort="Ru, Zeyuan" uniqKey="Ru Z" first="Zeyuan" last="Ru">Zeyuan Ru</name><name sortKey="Shi, Jian" sort="Shi, Jian" uniqKey="Shi J" first="Jian" last="Shi">Jian Shi</name><name sortKey="Wang, Cheng" sort="Wang, Cheng" uniqKey="Wang C" first="Cheng" last="Wang">Cheng Wang</name><name sortKey="Xie, Kairu" sort="Xie, Kairu" uniqKey="Xie K" first="Kairu" last="Xie">Kairu Xie</name><name sortKey="Xiong, Zhiyong" sort="Xiong, Zhiyong" uniqKey="Xiong Z" first="Zhiyong" last="Xiong">Zhiyong Xiong</name><name sortKey="Yang, Hongmei" sort="Yang, Hongmei" uniqKey="Yang H" first="Hongmei" last="Yang">Hongmei Yang</name><name sortKey="Zhang, Xiaoping" sort="Zhang, Xiaoping" uniqKey="Zhang X" first="Xiaoping" last="Zhang">Xiaoping Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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